Development and optimization of a novel PLGA-Levan based drug delivery system for curcumin, using a quality-by-design approach

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dc.authorid0000-0001-9519-3236
dc.contributor.authorBahadori, Fatemeh
dc.contributor.authorEskandari, Zahra
dc.contributor.authorEbrahimi, Nabiallah
dc.contributor.authorSennaroglu Bostan, Müge
dc.contributor.authorEroğlu, Mehmet Sayip
dc.contributor.authorToksoy Öner, Ebru
dc.contributor.otherRektörlük, Yabancı Diller Okulu
dc.contributor.otherRektörlük, Yabancı Diller Okulu
dc.date.accessioned2019-08-28T10:49:05Z
dc.date.available2019-08-28T10:49:05Z
dc.date.issued2019
dc.departmentİHÜ, Rektörlük, Yabancı Diller Okulu
dc.descriptionPubMed: 31394257
dc.description.abstractThis study aimed to develop a PLGA, Levan-based drug delivery system (DDS) of Curcumin using a quality-by-design (QbD) approach to reveal how formulation parameters affect the critical quality attributes (CQAs) of this DDS and to present an optimal design. First, a risk assessment was conducted to determine the impact of various process parameters on the CQAs of the DDS (i.e., average particle size, ZP, encapsulation efficiency and polydispersity index). Plackett–Burman design revealed that potential risk factors were Levan molecular weight, PLGA amount and acetone amount. Then, the optimization of the DDS was achieved through a Box–Behnken design. The optimum formulation was prepared using low molecular weight Levan (134 kDa), 51.51 mg PLGA and 10 ml acetone. The model was validated and the optimized formulation was further characterized using different physic-chemical methods. The study resulted in the most stable NP with a spherical and uniform shape and physical stability tests indicated its stability for at least 60 days at room temperature. In conclusion, this study was an effort for developing a DDS which solubilizes Curcumin in clinically applicable concentrations.
dc.identifier.citationBahadori, F., Eskandari, Z., Ebrahimi, N., Sennaroglu Bostan, M., Eroğlu, M. S., Toksoy Öner, E. (2019). Development and optimization of a novel PLGA-Levan based drug delivery system for curcumin, using a quality-by-design approach. European Journal of Pharmaceutical Sciences, 138, pp. 1-41.
dc.identifier.doi10.1016/j.ejps.2019.105037
dc.identifier.endpage41
dc.identifier.issn0928-0987
dc.identifier.issue138
dc.identifier.pmid31394257
dc.identifier.pmid31394257
dc.identifier.scopus2-s2.0-85070360943
dc.identifier.scopusqualityQ1
dc.identifier.startpage1
dc.identifier.urihttps://hdl.handle.net/20.500.12154/916
dc.identifier.wosWOS:000485819800018
dc.identifier.wosqualityQ2
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorEbrahimi, Nabiallah
dc.language.isoen
dc.publisherElsevier
dc.relation.ihupublicationcategory115
dc.relation.ispartofEuropean Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Öğrenci
dc.relation.publicationcategoryÖğrenci
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCurcumin
dc.subjectLevan
dc.subjectPLGA
dc.subjectQuality by Design
dc.subjectNano Drug Delivery
dc.subjectPlackett–Burman
dc.subjectBox– Behnken
dc.titleDevelopment and optimization of a novel PLGA-Levan based drug delivery system for curcumin, using a quality-by-design approach
dc.typeArticle
dspace.entity.typePublication
relation.isOrgUnitOfPublicationf4c26304-7b9a-4916-9825-7a183cc1197a
relation.isOrgUnitOfPublication.latestForDiscoveryf4c26304-7b9a-4916-9825-7a183cc1197a

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