Development and optimization of a novel PLGA-Levan based drug delivery system for curcumin, using a quality-by-design approach
Yükleniyor...
Dosyalar
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/embargoedAccess
Özet
This study aimed to develop a PLGA, Levan-based drug delivery system (DDS) of Curcumin using a quality-by-design (QbD) approach to reveal how formulation parameters affect the critical quality attributes (CQAs) of this DDS and to present an optimal design. First, a risk assessment was conducted to determine the impact of various process parameters on the CQAs of the DDS (i.e., average particle size, ZP, encapsulation efficiency and polydispersity index). Plackett–Burman design revealed that potential risk factors were Levan molecular weight, PLGA amount and acetone amount. Then, the optimization of the DDS was achieved through a Box–Behnken design. The optimum formulation was prepared using low molecular weight Levan (134 kDa), 51.51 mg PLGA and 10 ml acetone. The model was validated and the optimized formulation was further characterized using different physic-chemical methods. The study resulted in the most stable NP with a spherical and uniform shape and physical stability tests indicated its stability for at least 60 days at room temperature. In conclusion, this study was an effort for developing a DDS which solubilizes Curcumin in clinically applicable concentrations.
Açıklama
PubMed: 31394257
Anahtar Kelimeler
Curcumin, Levan, PLGA, Quality by Design, Nano Drug Delivery, Plackett–Burman, Box– Behnken
Kaynak
European Journal of Pharmaceutical Sciences
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
Sayı
138
Künye
Bahadori, F., Eskandari, Z., Ebrahimi, N., Sennaroglu Bostan, M., Eroğlu, M. S., Toksoy Öner, E. (2019). Development and optimization of a novel PLGA-Levan based drug delivery system for curcumin, using a quality-by-design approach. European Journal of Pharmaceutical Sciences, 138, pp. 1-41.
