Multicenter registry and test bed for extended outpatient hemodynamic monitoring: The hemodynamic frontiers in heart failure (HF2) initiative

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dc.authorid0000-0002-9037-5820
dc.contributor.authorHeywood, J. Thomas
dc.contributor.authorMunshi, Kartik
dc.contributor.authorJordan, Timothy R.
dc.contributor.authorMuse, Evan
dc.contributor.authorFudim, Marat
dc.contributor.authorSauer, Andrew J.
dc.contributor.authorMcDermott, Margaret
dc.contributor.authorShah, Hirak
dc.contributor.authorBhimaraj, Arvind
dc.contributor.authorKhedraki, Rola
dc.contributor.authorRobinson, Monique R.
dc.contributor.authorMcCann, Patrick
dc.contributor.authorVolz, Elizabeth
dc.contributor.authorGuha, Ashrith
dc.contributor.authorJonsson, Orvar
dc.contributor.authorBhatt, Kunjan A.
dc.contributor.authorBennett, Mosi K.
dc.contributor.authorBenjamin, Terrie Ann
dc.contributor.authorGuglin, Maya
dc.contributor.authorAbraham, Jacob
dc.contributor.otherİnsan ve Toplum Bilimleri Fakültesi, Psikoloji Bölümü
dc.date.accessioned2024-04-01T07:43:17Z
dc.date.available2024-04-01T07:43:17Z
dc.date.issued2023
dc.departmentİHÜ, İnsan ve Toplum Bilimleri Fakültesi, Psikoloji Bölümü
dc.description.abstractBackground: Hemodynamic Frontiers in Heart Failure (HF2) is a multicenter academic research consortium comprised of 14 US institutions with mature remote monitoring programs for ambulatory patients with heart failure (HF). The consortium developed a retrospective and prospective registry of patients implanted with a wireless pulmonary artery pressure (PAP) sensor. Goals/aims: HF2 registry collects demographic, clinical, laboratory, echocardiographic (ECHO), and hemodynamic data from patients with PAP sensors. The aims of HF2 are to advance understanding of HF and to accelerate development of novel diagnostic and therapeutic innovations. Methods: HF2 includes adult patients implanted with a PAP sensor as per FDA indications (New York Heart Association (NYHA) Class III HF functional class with a prior hospitalization, or patients with NYHA Class II or brain natriuretic peptide (BNP) elevation without hospitalization) at a HF2 member site between 1/1/19 to present. HF2 registry is maintained at University of Kansas Medical Center (KUMC). The registry was approved by the institutional review board (IRB) at all participating institutions with required data use agreements. Institutions report data into the electronic registry database using REDCap, housed at KUMC. Results: This initial data set includes 254 patients implanted from the start of 2019 until May 2023. At time of device implant, the cohort average age is 73 years old, 59.8% are male, 72% have NYHA Class III HF, 40% have left ventricular ejection fraction (LVEF) < 40%, 35% have LVEF > 50%, mean BNP is 560 pg/ml, mean N-Terminal pro-BNP (NTproBNP) is 5,490 pg/ml, mean creatinine is 1.65 mg/dl. Average baseline hemodynamics at device implant are right atrial pressure (RAP) of 11 mmHg, pulmonary artery systolic pressure (PASP) of 47 mmHg, pulmonary artery diastolic pressure (PADP) 21 mmHg, mean pulmonary artery pressure (mPAP) of 20 mmHg, pulmonary capillary wedge pressure (PCWP) of 19 mmHg, cardiac output (CO) of 5.3 L/min, and cardiac index (CI) of 2.5 L/min/m2. Conclusion: A real-world registry of patients implanted with a PAP sensor enables long-term evaluation of hemodynamic and clinic outcomes in highly-phenotyped ambulatory HF patients, and creates a unique opportunity to validate and test novel diagnostic and therapeutic approaches to HF.
dc.identifier.citationHeywood, J. T., Munshi, K., Jordan, T., Muse, E., Fudim, M., Sauer, A. J. ... Abraham, J. (2023). Multicenter registry and test bed for extended outpatient hemodynamic monitoring: The hemodynamic frontiers in heart failure (HF2) initiative. Frontiers in Cardiovascular Medicine, 10, 1-7. https://doi.org/10.3389/fcvm.2023.1321415
dc.identifier.doi10.3389/fcvm.2023.1321415
dc.identifier.endpage7
dc.identifier.issn2297-055X
dc.identifier.pmid38094114
dc.identifier.scopus2-s2.0-85179362230
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.3389/fcvm.2023.1321415
dc.identifier.urihttps://hdl.handle.net/20.500.12154/2769
dc.identifier.volume10
dc.identifier.wos1.12E+12
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorJordan, Timothy R.
dc.institutionauthorid0000-0002-9037-5820
dc.language.isoen
dc.publisherFrontiers
dc.relation.ispartofFrontiers in Cardiovascular Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectPulmonary Artery Pressure
dc.subjectPulmonary Hypertension
dc.subjectHeart Failure
dc.subjectHemodynamics
dc.subjectRemote monitoring
dc.subjectCardioMEMS
dc.titleMulticenter registry and test bed for extended outpatient hemodynamic monitoring: The hemodynamic frontiers in heart failure (HF2) initiative
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationd34be089-4b2e-4241-8353-5663a7b1a810
relation.isAuthorOfPublication.latestForDiscoveryd34be089-4b2e-4241-8353-5663a7b1a810
relation.isOrgUnitOfPublication85dd7f0d-d732-490e-9c57-18868e32298e
relation.isOrgUnitOfPublication.latestForDiscovery85dd7f0d-d732-490e-9c57-18868e32298e

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