Quality-by-design model in optimization of PEG-PLGA nano micelles for targeted cancer therapy

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dc.authorid0000-0001-9519-3236
dc.contributor.authorEskandari, Zahra
dc.contributor.authorKazdal, Fatma
dc.contributor.authorBahadori, Fatemeh
dc.contributor.authorEbrahimi, Nabiallah
dc.contributor.otherRektörlük, Yabancı Diller Okulu
dc.date.accessioned2018-11-26T12:37:56Z
dc.date.available2018-11-26T12:37:56Z
dc.date.issued2018
dc.departmentİHÜ, Rektörlük, Yabancı Diller Okulu
dc.description.abstractPoly (D,L-Lactic-co-Glycolic acid) (PLGA) is a biodegradable and biocompatible polymer approved by FDA for clinical uses. Surface functionalization of self-assembly micelles made of PLGA with Poly- Ethylene Glycol (PEG) improves its stability and half-life in blood circulation via inhibiting adsorption of proteins on the surface and consequently decreasing opsonization rate. The purpose of present study was to optimize PEG amount absorbed on PLGA (PEGabsPLGA) micelles by application of quality by design approach. Based on risk assessment, effect of three variables including PLGA concentration, PEG concentration and molecular weight (MW) of PLGA were studied. Central composite design was implemented for design of experimentation with 26 runs. The PEGabsPLGA nano drug delivery system (NDDS), produced by o/w method, was optimized according to particle size, polydispersity index (PDI) and zeta potential values. Validation of the model was successfully performed with three representative formulations from the design space. As a result, 43.79 mg of PLGA with MW of 30,000-60,000 was incorporated with 12.61 mg of PEG to obtain a 69 nm NDDS (predicted 67.72 nm) with the PDI value equal to 0.124 (predicted 0.112). The results successfully led to the preparation of the most stable nanoparticles which were stable at room temperature for six months.
dc.identifier.citationEskandari, Z., Kazdal, F., Bahadori, F., Ebrahimi, N. (2018). Quality-by-design model in optimization of PEG-PLGA nano micelles for targeted cancer therapy. Journal of Drug Delivery Science and Technology, 48, pp. 393-402. http://dx.doi.org/10.1016/j.jddst.2018.10.009
dc.identifier.doi10.1016/j.jddst.2018.10.009
dc.identifier.endpage402
dc.identifier.issn1773-2247
dc.identifier.issn2588-8943
dc.identifier.scopus2-s2.0-85055278898
dc.identifier.scopusqualityQ1
dc.identifier.startpage393
dc.identifier.urihttp://dx.doi.org/10.1016/j.jddst.2018.10.009
dc.identifier.urihttps://hdl.handle.net/20.500.12154/552
dc.identifier.volume48
dc.identifier.wosWOS:000451008000044
dc.identifier.wosqualityQ2
dc.indekslendigikaynakScopus
dc.indekslendigikaynakWeb of Science
dc.institutionauthorEbrahimi, Nabiallah
dc.language.isoen
dc.publisherEditions de Sante
dc.relation.ihupublicationcategory115
dc.relation.ispartofJournal of Drug Delivery Science and Technology
dc.relation.publicationcategoryMakale - Ulusal - Editör Denetimli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCentral Composite Design
dc.subjectDrug Delivery System
dc.subjectPEG-PLGA
dc.subjectQuality by Design
dc.subjectTargeted Cancer Therapy
dc.titleQuality-by-design model in optimization of PEG-PLGA nano micelles for targeted cancer therapy
dc.typeArticle
dspace.entity.typePublication
relation.isOrgUnitOfPublicationf4c26304-7b9a-4916-9825-7a183cc1197a
relation.isOrgUnitOfPublication.latestForDiscoveryf4c26304-7b9a-4916-9825-7a183cc1197a

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