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Yayın A cross-cultural investigation of effective language pedagogy in teachers’ personal practical knowledge narratives: A cultural-ecological perspective(Routledge, 2024) Kamalivahedazad, Jaber; Rektörlük, Yabancı Diller OkuluThe current case study probes two international language teachers’ perspectives on the role culture plays in their perception of an effective language pedagogy through their personal practical knowledge narratives from a cultural ecological standpoint. To do this, two language teachers from two different cultural backgrounds (Iran and Japan) were asked to write a narrative about an effective class they had taught and how culture had influenced it. These narratives were read carefully and became the basis of three 60-minute semi-structured narrative interviews. Both narratives and interview data were analysed using a thematic analysis based in a cultural ecological perspective. The study contributes to the literature on culturally informed education by recognising culture as a distinctive factor affecting learning in different layers of the cultural ecology and can inform a culture-specific, nativized teacher education programme.Yayın An ecological inquiry into the identity formation of a novice TESOL research mentor: Critical autoethnographic narratives in focus(SAGE Publications, 2024) Kamali, Jaber; Kamalivahedazad, Jaber; Rektörlük, Yabancı Diller OkuluThis study reports on the identity formation of the author as a novice research mentor of an independent research course for TESOL teachers over six months (from the course design to the first research submission). The data is collected from four critical autoethnographic narratives written by the author before, during, and after this period. The narratives were analysed thematically with an eye on the theoretical underpinning of the study, i.e. ecological perspective, in three ecological layers namely micro-, meso-, and macrosystem. The results revealed that the author’s identity construction was influenced by different factors such as ‘autonomy in mentoring’, ‘mediating mentorship’, or ‘academic recognition’ in three levels of educational ecology. The results of this study can motivate research mentors and teacher educators, specifically novice ones, to find some similarities with the ideas discussed in this research and to record their lived experiences as a tool for reflection.Yayın Development and optimization of a novel PLGA-Levan based drug delivery system for curcumin, using a quality-by-design approach(Elsevier, 2019) Bahadori, Fatemeh; Eskandari, Zahra; Ebrahimi, Nabiallah; Sennaroglu Bostan, Müge; Eroğlu, Mehmet Sayip; Toksoy Öner, Ebru; Rektörlük, Yabancı Diller OkuluThis study aimed to develop a PLGA, Levan-based drug delivery system (DDS) of Curcumin using a quality-by-design (QbD) approach to reveal how formulation parameters affect the critical quality attributes (CQAs) of this DDS and to present an optimal design. First, a risk assessment was conducted to determine the impact of various process parameters on the CQAs of the DDS (i.e., average particle size, ZP, encapsulation efficiency and polydispersity index). Plackett–Burman design revealed that potential risk factors were Levan molecular weight, PLGA amount and acetone amount. Then, the optimization of the DDS was achieved through a Box–Behnken design. The optimum formulation was prepared using low molecular weight Levan (134 kDa), 51.51 mg PLGA and 10 ml acetone. The model was validated and the optimized formulation was further characterized using different physic-chemical methods. The study resulted in the most stable NP with a spherical and uniform shape and physical stability tests indicated its stability for at least 60 days at room temperature. In conclusion, this study was an effort for developing a DDS which solubilizes Curcumin in clinically applicable concentrations.Yayın Metamorphosis of a teacher educator: A journey towards a more critical self(Kaplan Higher Education Academy, 2023) Kamali, Jaber; Kamalivahedazad, Jaber; Rektörlük, Yabancı Diller OkuluCritical teacher education emerged as a response to the liberal, hegemonic, and power-oriented world that affected teacher education as well. Albeit widely discussed, moving towards becoming this type of teacher educator is neither easy nor fast. This autoethnographic narrative study describes my journey as a teacher educator from a non-critical, product-oriented, passive teacher educator to a more critical, process- oriented, active teacher educator who learns, questions, relearns, and unlearns. The data are gathered from different sources of my personal portfolio, including training diaries, field notes, memories, feedback, and observation. The findings of the study reveal the underlying factors that shape our thoughts, beliefs, and practices and how we can gain voice and agency and transform into critical teacher educators.Yayın Quality-by-design model in optimization of PEG-PLGA nano micelles for targeted cancer therapy(Editions de Sante, 2018) Eskandari, Zahra; Kazdal, Fatma; Bahadori, Fatemeh; Ebrahimi, Nabiallah; Rektörlük, Yabancı Diller OkuluPoly (D,L-Lactic-co-Glycolic acid) (PLGA) is a biodegradable and biocompatible polymer approved by FDA for clinical uses. Surface functionalization of self-assembly micelles made of PLGA with Poly- Ethylene Glycol (PEG) improves its stability and half-life in blood circulation via inhibiting adsorption of proteins on the surface and consequently decreasing opsonization rate. The purpose of present study was to optimize PEG amount absorbed on PLGA (PEGabsPLGA) micelles by application of quality by design approach. Based on risk assessment, effect of three variables including PLGA concentration, PEG concentration and molecular weight (MW) of PLGA were studied. Central composite design was implemented for design of experimentation with 26 runs. The PEGabsPLGA nano drug delivery system (NDDS), produced by o/w method, was optimized according to particle size, polydispersity index (PDI) and zeta potential values. Validation of the model was successfully performed with three representative formulations from the design space. As a result, 43.79 mg of PLGA with MW of 30,000-60,000 was incorporated with 12.61 mg of PEG to obtain a 69 nm NDDS (predicted 67.72 nm) with the PDI value equal to 0.124 (predicted 0.112). The results successfully led to the preparation of the most stable nanoparticles which were stable at room temperature for six months.Yayın Transnational language teachers emotional vulnerability and professional identity construction: An ecological perspective(Routledge, 2023) Kamali, Jaber; Nazari, Mostafa; Kamalivahedazad, Jaber; Rektörlük, Yabancı Diller OkuluDespite the recent growth of attention to language teachers’emotionalvulnerability, little research has explored emotional vulnerability andidentity construction among transnational teachers. Drawing on anecological theoretical lens, we explored the emotional vulnerability andprofessional identity construction of transnational language teachersworking in the context of Turkey. Data were collected from open-endedquestionnaires, narrative frames, and semi-structured interviews. Dataanalysis revealed that across the three classroom (micro), institutional(meso), and sociocultural (macro) ecologies, the transnational teachersexperienced contextually-invoked emotional conflicts that positionedtheir identities in a vulnerable state. Most notably, we found thattransnational teachers need to become contextually adaptable to thethree ecologies in order to develop professional coping strategies thatsafeguard them against the chronicle stressors of their profession andcontext. We situate such adaptability within implications calling forholding preparatory courses that facilitate transnational teachers’transition to the new setting with the hope of positively contributing totheir effective professional identity construction.